On 01/25/2013 01:39 AM, Archimedes Plutonium wrote: > Basically I am just simply asking for what mathematical advantage for > mutations arises for inbreeding. I do not know if any biologist has > researched this question. The question of how much faster or how much > more mutations accrue when a population of a species has inbreeding. > Such as when 1 male and 1 female are stranded on a island and up to > those 2 individuals to keep their kind growing. So there is much > inbreeding. And not outside mating. So that all generations on the > island trace their ancestors back to those starting 2. > > Compare that population with an equal sized population that has no > inbreeding. > > I would hazard to guess that the mutations of the inbreeding > population would be far ahead of the non inbreeding population. > > And I think this is how so many islands that are isolated from their > mainland have so many different species that the mainland does not > have, is because of what I call the species accelerant of inbreeding. > > So that Neanderthal was two Africans that migrated north out of Africa > some 400,000 years ago and because of inbreeding ended up as different > species of the Africans who migrated enmasse some 60,000 years ago. > > So that the Clovis man who migrated to the Americas, either out of > Asia or Europe some 15,000 years ago, if Clovis man had been a single > 1 male and 1 female and populated the Americas, that by the time of > Columbus would have found, not the same species of Homo sapiens, but > perhaps a different species. So here we have a sort of scientific > prediction or question, of how many Clovis people migrated to the > Americas some 15,000 years ago so that their genetic stock was > sufficient to not mutate too much so that by the time Columbus > arrived, they would still be the same Homo sapiens species. > > So we need some biology research into what sort of mutation rate is > increased in populations with inbreeding versus populations of > noninbreeding. > > And in sociology we can recognize the problem of the American Indians > in that they needed tribal interactions with other diverse tribes > because of inbreeding. > > Usually inbreeding brings out deleterious mutations, and rarely does > it bring out advantageous mutations. > > Now I would be deeply surprised if no biologist has done research on > this before, of extracting a number for mutation rate in a > noninbreeding population and a mutation rate in a inbreeding > population. > > So if we had such a numbers figure for this mutation accelerant and > applied that numbers to Clovis Man, we may be able to roughly estimate > how many individuals, male and female crossed over into the Americas. [...]
Some common genetic diorders are single-gene recessive, meaning that one good allele and one bad allele makes for an Ok baby (a carrier), but two bad alleles makes for a "bad" baby who exhibits or manifests the disease linked to the "bad allele".
And two good alleles makes an Ok baby also.
That's for the genes carried on the non-sexual chromosomes. For diseases single gene recessive on the X sexual chromosome, one allele bad of the gene on the X-chromosome makes for a "bad baby" if it's male, cause the male has one X and one Y sex-chromosome. But a female baby with two X-chomosomes and 1 good and 1 bad allele would be an Ok baby, but still a carrier. This happens with hemophilia, if memory serves me well.
The genes that make for a strong baby who will reproduce with optimal number of off-spring is highly non-trivial.
Some game theory could be involved and there could be several optimal fitness genomes; also, variation of gene pool could be an asset for a loosely-bound tribe.
Maybe some models can say something about the optimal strategy for an individual, like say considering marrying a second-cousin by age 37 if all else fails. It's just speculation on my part that such studies/simulations/models exist.
dave -- dracut:/# lvm vgcfgrestore File descriptor 9 (/.console_lock) leaked on lvm invocation. Parent PID 993: sh Please specify a *single* volume group to restore.