Go for 64-bit version. 1. Download and install Microsoft .Net Framework 4.5(dotNetFx45_Full_setup.exe) [ignore if you already have] 2. Uninstall Microsoft Visual C++ 2010 (both x64 and x86) from control panel. 3. Download(GRMSDKX_EN_DVD.iso) and install Windows SDK 7.1 (it is the compiler) It will restore Microsoft Visual C++ 2010 on ur pc. Steps 1 & 2 are necessary for 3. 4. Run Matlab as administrator and type: mex -setup Follow steps to set SDK as your default compiler. 5.Download matlab plugin of photoshop from http://download.adobe.com/pub/adobe/photoshop/win/13.x/Win_MATLAB_Plug-In.zip 6.Create a folder MATLAB at C:\Program Files\Adobe\Adobe Photoshop CS6 (64 Bit) and transfer the contents of MATLAB_Win64 into it. 7. Create a folder MATLAB at C:\Program Files (x86)\Adobe\Adobe Photoshop CS6 (64 Bit) and transfer the contents of MATLAB_Win32 into it. 8. Run Matlab as ADMINISTRATOR and Set matlab path to MATLAB folder of step 5 according to the pdf. 9. Follow other steps of pdf.