Date: Sep 4, 1996 7:04 AM Author: David Wilson Subject: Re: Several questions on evolution, and mutation (rate)

Note followups.

In article <Pine.A32.3.91.960815144016.39360B-100000@flute.aix.calpoly.edu>

<asinger@flute.aix.calpoly.edu> (Andrew Singer) wrote:

> .. I just pick up the book "Darwin on Trial" by Phillip Johnson

>

> ... Let me take a quick excerpt from the book from which I have a few

> questions to throw out:

> "..the mathematician D.S. Ulam argued that it was highly

> improbable that the eye could have evolved by the accumulation of small

> mutations, because the number of mutations would have to be so large and

> the time available was not nearly long enough for them to appear..."

>

This quotation seems to be typical of the general quality of scholarship

Johnson displays in his book. In the first place, he gets the name wrong.

Stanislaw Ulam (or S.M. Ulam) was a well-known and highly respected

mathematician. He was also the only person with that surname to have

presented a paper at the meeting which Johnson was referring to. In the

second place, Johnson's claim, "...Ulam argued that it was highly improbable

that the eye could have evolved by the accumulation of small mutations...",

is simply false; Ulam did no such thing.

Near the beginning of his paper, Ulam explicitly stated that the mathematical

models he was going to present were "certainly ... not correct in a realistic

sense", to use his own words. His main aim was to present some models which

might serve as a starting point for the development of better ones, and to

challenge the biologists present to find ways of determining the values of

various parameters that would be needed for any such models to be useful.

His remarks indicated that it would be a long time, in his opinion, before

these models would ever become sufficiently accurate to be of any practical

use.

> Now I have a ton of questions stemming from this one sentence. I hope

> someone out there can help.

>

> 1- How does someone determine how long it would take for a series of

> mutations to occur (all being presumably favorable mutations)?

>

In the paper which Johnson was referring to, Ulam outlined some ideas for

models aimed at answering this question for 3 forms of reproduction:

asexual, sexual with random mating, and sexual with recognition of

favourable phenotypes and preferential mating between them. Of the last

two, he presented very few specific details. Even for his first model,

he did not give enough details for anyone reading the paper to reconstruct

it exactly. However, he did give enough to provide a pretty fair idea of

how it worked. Some of its main features were:

1. Fixed population size, N

2. Fixed time interval t between generations.

3. A number F of successive favourable mutations is needed for the organism

to acquire a certain novel characteristic.

4. With respect to this series of favourable mutations, each individual has

a fixed probability 1-p of being born with exactly the same "genetic

complement" as its parent and a probability p of being born with the

favourable mutation which is next in the series from the one which its

parent carried.

5. An organism with a favourable mutation produces an (average?) number

of offspring which is a fixed multiple 1 + g of the (average?) number

produced by one without it.

By way of illustration, Ulam took N = 10^11, t = 1 day, F = 10^6

p = 10^(-10) and g = 10^(-6). Without providing details of his calculation,

he stated that with these parameters the model would give 10^(13) as the

number of generations required for most of the population to acquire the

novel characteristic in question. At 1 generation per day, this would amount

to some 27 billion years, so it is presumably this calculation which Johnson

is relying upon to justify his claim about Ulam's argument. However, Ulam

himself drew _no_ factual conclusions whatsoever from his calculations,

either about the probability of the evolution of the eye, or about any other

aspect of evolution.

>

> 2- How accurate should one assume these calculations are?

>

As I indicated above, Ulam explicitly admitted that his models were

unrealistic. He also noted that the values of most of the parameters he

used in his calculations were unknown by up to several of orders

of magnitude, and could well have been off by that amount.

--------------------------------------------------------------------

David Wilson

david@defcen.gov.au