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Luis A. Afonso
Posts:
4,758
From:
LIsbon (Portugal)
Registered:
2/16/05


Polio, Salk vaccine
Posted:
Dec 27, 2012 10:10 AM


Quoting
www.tamiu.edu/~cferguson/Ferguson PPRP.pdf   An Effect Size Primer: A Guide for Clinicians and Researchers Christopher J. Ferguson Texas A&M International University
. . . Rosnow and Rosenthal (2003) discuss the effectiveness of the Salk vaccine on polio. From a treatment group (n = 200,745) receiving the Salk vaccine, 33 later had polio develop. From a control group (n = 201,229), polio developed in 115. _______________
Let be __X0= 115, n0=201228 __X1= 33, n1=200475 And _____z = (x0/n0  x1/n1)/sqrt [pp*(1pp)*(1/n0+1/n1)] pp=(x0+x1)/(n0+n1) _____z= 6.71880, which gave a pvalue1E11 (z=6.70602, Abramowitz, Stegun, Handbook of Mathematical Functions). COMMENT If is accepted that proportions can be treated as asymptotically normal (even very away from p=0.5, which is uppermost risky) one can safely state that the vaccine is effective. Performing a NoNHST one can state that by million of children it was expected that 571 be infected. If vaccinated at least 50.4% will not be infected (5% significance level). At late 1940´s, in Portugal, I got a full hand of high school colleagues.
Luis A. Afonso



