The disease sequence-progression of Prion and Alzheimers
Now in the PBS Newshour of Friday, March 15, Miles OBrien went to the Wise Laboratory of Univ Southern Maine to see how dangerous Chromium 6 was to health and he shows a slide of a cell in replication of mitosis, only instead of there being 2 centrosomes, there were 4 centrosomes-- very very dangerous. Now we can take a clue or link to Alzheimers and Prion disease where we have a waste build-up of plaques in the brain. Plaque build-up is where protein filaments stick together in clusters and thus unable to be removed. So now, if Chromium 6 can mess up centrosomes so that there are 4 centrosomes when there should be only 2, means that metals can cause a ?clumping of proteins when no clumping is wanted. In other words, the ?metal caused two more clumps of genes. So if chromium 6 can cause ?centers of clumping when none should clump, then metals can be the ?same mechanism that causes plaques in Alzheimers or Prion.
Now let us spend some time with Prion disease and what its likely mechanism is when mercury is its causative agent.
Chromium-6 is not involved in Prion disease, at least that is my present understanding since hexavalent chromium cannot pass through the blood-brain-barrier but mercury compounds easily pass through.
If I recall correctly the normal body makes prion proteins as substance for the walls of cells. And pictures of these molecules shows they contain metals such as copper and zinc as normal prions. In the case of the disease, the body makes too much of the protein and the overload starts clumping together. Much like Alzheimers where it starts clumping into beta amyloid or tau plaques, only in the case of Prion disease, it clumps in prion proteins. So that Alzheimers is very similar in its mechanism of an unwanted protein, where the body makes too much and where the body clean-up cannot get rid of the protein build-up.
So far, it sounds like mercury or compound of mercury acting like a catalyst. If you remember a catalyst in chemistry speeds up a reaction and ends up leaving the catalyst untouched at the end.
So for Prion disease, or Alzheimers, some mercury compound, let us guess mercuric-cesium or mercuric cadmium or mercuric fluorine, some other compound gets into the brain of an individual and meets the processing of prion proteins where it becomes incorporated into the processing that then spews out mis-shappened prion proteins instead of normal proteins. In the case of Alzheimers, the mercuric compound gets into the manufacturing process of normal tau and beta molecules and becomes part of that manufacturing process where it produces mis- shappened tau and beta molecules. And because it is a catalyst, wrecking the manufacturing of proteins, the dangerous disease causing mercury keeps going around altering the protein manufacturing process.
If I remember correctly both Prion and Alzheimers require a threshold of bad proteins to initiate the disease, which if true, rings of the idea of a toxin threshold. And in the case of Prion disease, when other animals eat the brains of an infected animal, it is not the prions that are the danger, but the mercury compound that started the disease.
Now that makes a startling prediction that if the brains of an Alzheimers victim were eaten, that the mercury compound could cause the disease all over again in the person doing the consuming. Or, it may predict that some rare cases of people who contract both Prion disease and Alzheimers simultaneously due to the mercury catalyst involved.
Only Drexel's Math Forum has done a excellent, simple and fair ?author- archiving of AP posts for the past 15 years as seen here: